Completed Enrollment

Study of BTK Inhibitor LOXO-305 Versus Approved BTK Inhibitor Drugs in Patients With Mantle Cell Lymphoma (MCL) (BRUIN-MCL-321)

This is a study for participants with a type of blood cancer called mantle cell lymphoma (MCL). The main purpose is to compare pirtobrutinib to other drugs that work in a similar way that have already been approved by the United States Food and Drug Administration (US FDA).

Trial Summary

Age Range
≥18 years
Conditions the trial is for
Mantle Cell Lymphoma
What the trial is testing?
Acalabrutinib, Ibrutinib, Pirtobrutinib, Zanubrutinib
Could I receive a Placebo?
No
Enrollment Goal
500
Trial Dates
Apr 8, 2021 - Jul 2026
How long will I be in the trial?
Participation could last up to two years, and possibly longer, if the disease does not progress.
Trial Phase
III

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Have mantle cell lymphoma

  • Have already had treatment

  • Be well enough to perform their own personal care

  • Have adequate organ function and blood counts, as measured by blood tests

Participants Must Not:

  • Have taken the same kind of drug that is being studied in this trial

  • Have an abnormal tendency to bleed

  • Have had a stroke or bleeding in the brain within the last six months

  • Have serious heart disease

  • Have any problems absorbing food or medicine taken by mouth

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